200 $
CUMYL-PINACA powder designer cannabinoid and a great analogue of marijuana. It has long established itself in the market for research chemicals, as a cannabinoid. Therefore, true appreciated qualities continue to conduct their experiments with this cannabinoid.
5F-Cumyl-PINACA, also known as 1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide, is a synthetic cannabinoid. It is part of a class of compounds designed to mimic the effects of delta-9-tetrahydrocannabinol (THC), the active component in cannabis. This compound has gained attention due to its potent agonistic activity at cannabinoid receptors, particularly CB1 and CB2 receptors .
The synthesis of 5F-Cumyl-PINACA involves several steps:
Starting Materials: The synthesis begins with commercially available starting materials such as indazole and fluoropentyl bromide.
Reaction Steps:
Reaction Conditions: The reactions typically require anhydrous conditions and inert atmosphere (e.g., nitrogen or argon) to prevent unwanted side reactions.
5F-Cumyl-PINACA undergoes various chemical reactions:
Oxidation: The compound can be oxidized at the fluoropentyl chain, leading to hydroxylated metabolites.
Reduction: Reduction reactions are less common but can occur under specific conditions.
Substitution: The fluorine atom in the pentyl chain can be substituted with other nucleophiles under appropriate conditions.
Common Reagents and Conditions: Oxidizing agents like potassium permanganate and reducing agents like lithium aluminum hydride are used. Substitution reactions may involve nucleophiles such as thiols or amines.
Major Products: The primary products include hydroxylated derivatives and substituted analogs.
5F-Cumyl-PINACA has several scientific research applications:
Chemistry: It is used as a reference standard in analytical chemistry for the detection and quantification of synthetic cannabinoids in biological samples.
Biology: The compound is studied for its interaction with cannabinoid receptors, providing insights into receptor binding and activation mechanisms.
Medicine: Research focuses on its potential therapeutic effects and adverse effects, contributing to the understanding of synthetic cannabinoids’ impact on human health.
Industry: It is used in the development of new synthetic cannabinoids for various applications, including potential pharmaceutical uses
5F-Cumyl-PINACA acts as a potent agonist for cannabinoid receptors: CUMYL-PINACA powder
Molecular Targets: It primarily targets CB1 and CB2 receptors.
Pathways Involved: Upon binding to these receptors, it activates G-protein coupled receptor pathways, leading to the inhibition of adenylate cyclase and subsequent decrease in cyclic AMP levels.
5F-Cumyl-PINACA is compared with other synthetic cannabinoids:
Similar Compounds: Cumyl-PINACA, 5F-APINACA, AB-PINACA, and 5F-PB-22.
Uniqueness: this compound is unique due to its high potency and selectivity for CB1 receptors. . CUMYL-PINACA powder
IUPAC Name |
1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide | |
|---|---|---|
InChI |
InChI=1S/C22H26FN3O/c1-22(2,17-11-5-3-6-12-17)24-21(27)20-18-13-7-8-14-19(18)26(25-20)16-10-4-9-15-23/h3,5-8,11-14H,4,9-10,15-16H2,1-2H3,(H,24,27) | |
InChI Key |
XSHGVIPHMOTDCS-UHFFFAOYSA-N | |
Canonical SMILES |
CC(C)(C1=CC=CC=C1)NC(=O)C2=NN(C3=CC=CC=C32)CCCCCF | |
Molecular Formula |
C22H26FN3O | |
| DTXSID701032564 | ||
Molecular Weight |
367.5 g/mol | |
CAS No. |
1400742-16-6 |
Please be aware that all articles and product information presented on BenchChem are intended solely for informational purposes. The products available for purchase on BenchChem are specifically designed for in-vitro studies, which are conducted outside of living organisms. In-vitro studies, derived from the Latin term “in glass,” involve experiments performed in controlled laboratory settings using cells or tissues. It is important to note that these products are not categorized as medicines or drugs, and they have not received approval from the FDA for the prevention, treatment, or cure of any medical condition, ailment, or disease. We must emphasize that any form of bodily introduction of these products into humans or animals is strictly prohibited by law. It is essential to adhere to these guidelines to ensure compliance with legal and ethical standards in research and experimentation.
are the largest and most structurally diverse class of new psychoactive substances, with manufacturers often using isomerism to evade detection and circumvent legal restriction. The regioisomeric methoxy? and fluorine?substituted analogs of SDB?006 (N?benzyl?1?pentyl?1H?indole?3?carboxamide) were synthesized and could not be differentiated by gas chromatographymass spectrometry (GCMS), but were distinguishable by liquid chromatographyquadrupole time?of?flightMS (LCQTOFMS). In a fluorescence?based plate reader membrane potential assay, SDB?006 acted as a potent agonist at human cannabinoid receptors (CB1 EC50 = 19 nM). All methoxy? and fluorine?substituted analogs showed reduced potency compared to SDB?006, although the 2?fluorinated analog (EC50 = 166 nM) was comparable to known synthetic cannabinoid RCS?4 (EC50 = 146 nM). Using biotelemetry in rats, SDB?006 and RCS?4 evoked comparable reduction in body temperature (~0.7°C at a dose of 10 mg/kg), suggesting lower potency than the recent synthetic cannabinoid AB?CHMINACA (>2°C, 3 mg/kg).
| Quantity | 10g, 20g, 1kg |
|---|
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