JWH-307 CRYSTAL

JWH-307 CRYSTAL is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7 nM at CB1 vs 3.3 nM at CB2. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany. JWH-307 CRYSTAL?-Isomer is an analogue of JWH-307 CRYSTAL(J211800), a cannabimimetic that potently activates both the central cannabinoid (CB) receptor, CB1, and the peripheral CB2 receptor (Ki = 7.7 and 3.3 nM, respectively). The affinities of JWH-307 for both CB1 (Ki = 7.7 nM) and CB2 (Ki = 3.3 nM) are comparable to those of the traditional cannabinoid.

Technical Information on JWH-307 CRYSTAL

Formal Name: [5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-methanone
CAS Number: 914458-26-7
Molecular Formula: C26H24FNO
Formula Weight: 385.5
Purity: ?96%
Formulation: A crystalline solid
?max: 217, 250 nm
SMILES: O=C(C1=CN(CCCCC)C(C2=CC=CC=C2F)=C1)C3=C4C(C=CC=C4)=CC=C3
InChi CodeInChI=1S/C26H24FNO/c1-2-3-8-16-28-18-20(17-25(28)23-13-6-7-15-24(23)27)26(29)22-14-9-11-19-10-4-5-12-21(19)22/h4-7,9-15,17-18H,2-3,8,16H2,1H3
InChi Key: WYNZPDDTQGVCLZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 1 year

See also
JWH-147
WARNING This product is not for human or veterinary use.

JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2?-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands. Other 2?-substituted analogues such as the methyl, chloro and bromo compounds are also active and somewhat more potent.